Purpose: To evaluate the effectiveness and safety of riboflavin/UVA corneal cross-linking in the treatment of persistent corneal infections. Study design : Intervention case series study.Methodology : Study group : Patients with clinical manifestations of persistent infectious keratitis(10 patients), 3 females and 7 males, with inclusion criteria of persistent acanthamoeba keratitis, fungal keratitis and bacterial keratitis. Keratitis of unknown cause ( Persistent means failure of medical treatment for one month ) treated by corneal crosslinking by ri boflavin and UVA.Results: In 80% resistant infections were completely eliminated with complete healing of the ulcer by treatment of CXL by riboflavin and UVA, improvem ent was happened in 10% and failure was happened in 10% due to rapid deterioration. Visual acuity improved in 50% .Conclusion: CXL by riboflavin and UVA can be an effective method in the treatment of resistant corneal infections.