Aim of the work: The aim of this work was to detect if new imaging modality(tissue Doppler) provides earlier insight into cardiovascular involvement in SLE and seem to be superior to standard echocardiography to determine subclinical cardiovascular involvement in SLE& to investigate parameters that could predict cardiac dysfunction in SLE patients in the absence of any symptoms or signs suggestive of cardiovascular involvement.Patients& methods: 50 female SLE patients attending Rheumatology &Rehabilitation department in Kasr El Aini hospital, Cairo University compromised the subject of this study .All patients were subjected to full history taking, clinical & laboratory investigations. All underwent 2D echocardiography & tissue Doppler. 20 healthy females age matched was taken as control.Results: Standard 2-dimensional echocardiography parameters were within normal range in SLE patients ,while assessment using tissue Doppler ,it showed significant impairment in peak systolic velocity at septum &mitral (P=.004 at both sites), peak early diastolic velocity at septum& mitral (p=.018,.001 respectively), peak late diastolic velocity at septum &mitral (p=.004,.018 respectively) , isovolumetric relaxation time (p=.001, .002 respectively)& myocardial performance index at septum &mitral (p=.000 at both sites)) compared to control group. Furthermore SLE patients with longer disease duration>10, higher disease activity (SLEDAI>10),hypertensive & older age showed significantly impaired systolic & diastolic myocardial velocities, prolonged isovolumetric relaxation time& higher myocardial performance index measured by tissue Doppler .Conclusion: SLE is associated with subclinical systolic and diastolic dysfunction. Tissue Doppler seems to be superior to standard echocardiography to detect subclinical myocardial disease.