According to the results of our study and taking into account the possibility of existence of dysfunctional larynx following radiotherapy as primary treatment modality in patients with advanced laryngeal cancer, we can conclude that total laryngectomy and ipsilateral or bilateral neck dissection followed by postoperative radiotherapy should be considered as a recommendable treatment approach in patients with resectable advanced laryngeal cancer. In order to improve treatment results in terms of LRC and OS and following evidence-based treatment recommendations for patients with advanced laryngeal cancer whose initial treatment is radical surgery, we strongly advocate the acceptance of postoperative concurrent chemoradiotherapy in cases with surgical specimen demonstrating high-risk pathological features.