Genome wide association studies have been performed in Psoriasis in several ethnic groups but never in Egyptians. The objective of this study is to determine the genetic susceptibility in Egyptian psoriasis patients. Blood samples from 339 Egyptian patients were withdrawn and more than 200,000 SNP’s were scanned using microarray Techniques. HLA Cw*06 and other novel susceptibility Loci were found to be positively associated with psoriasis.