Nephrotic syndrome is applicable to any condition with heavyproteinuria, hypoproteinaemia, generalized edema and hyperlipidaemia.It is a common chronic childhood disorder. The main aim oftreatment is to induce and maintain a remission as well as maintaingood lifestyle for the patient and avoid adverse effects of the diseaseand therapy. Corticosteroids remain the mainstay of treatment and in resistantcases the use of many immunosuppressive agents with differentprotocols have been tried. Foremost is knowing the main side effectsand monitoring of these drugs to avoid hazardous complications.