Objective: The aim of this work is to evaluate the variable outcomes of surgical excision of cortical lesions in eloquent areas of the brain using the awake craniotomy technique. Methods: In our study, Patients having lesions in eloquent brain areas were evaluated pre-operatively both clinically and radiologically and Subjected to awake craniotomy Operative procedures including debulking, subtotal resection, and gross total resection. Postoperatively, patients were evaluated and followed up for their neurological integrity, deficits and outcome. Results: we operated upon 10 patients under awake craniotomy technique, the median age of presentation in this study was 42 years. There were 6 males (60 %) and 4 females (40 %). Three patients (30%) had pre-operative focal neurological deficits. We achieved gross total resection in one patient (10%), tumor debulking in two patients (20%) and subtotal resection in six patients (60%), the last (10th) patient died 6 hours after surgery. Postoperatively, two patients (20%) had transient new onset neurological deterioration and one patient (10%) had permanent new onset neurological deterioration. The three patients presented pre-operatively with focal neurological deficits did not deteriorate and continue as preoperatively. Three patients (30%) had excellent outcomes, four patients (40%) had good outcomes, two patients (20%) had fair outcomes, and one patient (10%) had poor outcome. Conclusion: Functional neurological outcome following resection of cortical lesions in eloquent areas proved to be extensively related to pre-operative neurological integrity ,extent of resection and tumor histopathology, and that outcome is deeply influenced by the adoption of awake craniotomy and the use of intra-operative techniques that allow for wide surgical resection while minimizing the risk of postoperative neurological deterioration.