Breast carcinoma is the foremost malignancy in females. It is a heterogenous disease that needs several immunohistochemical markers to predicte the prognosis and select the appropriate treatment. Atypical breast lesions are associated with increased risk to develop breast carcinoma. Thus it is important not only to diagnose these lesions, but also to identify prognostic features for development of carcinoma. E- cadherin is a cell adhesion molecule and it has a major role in the maintenance of intercellucar junctions between epithelial cells in most organs. Thus, inactivation of E- cadherin causes d ``disruption of cell- cell adhesion and this is characteristic of the cell with malignant transformation. This work aimed at study of breast carcinoma and atypical breast lesions with assessment of E- cadherin expression in these lesions to evaluate its significance.