The purpose of the present study was to investigate Fracture Resistance, Marginal Accuracy and Mode of Fracture of the CAD/CAM translucent zirconia three unit posterior bridges. The number of models used for this study were 20. All 20 models were constructed into a three unit FPD bridge with full coverage retainers on both abutments, restoring the maxillary second permanent premolar. The constructed 20 models, were divided prior to construction into two different groups, according to the material used in model construction. Each of the studied groups consisted of 10 models. The first group of FPDs was constructed using veneered zirconia cores. The second group of FPDs was constructed using Zirconia full anatomical bridge. The bridges were made using the Cerec in Lab 3.88 CAD/CAM system, which is one of the best systems used in FPD construction owed to its highly accurate scanning, design and milling. Marginal accuracy, fracture resistance and mode of fracture were determined for the bridge models. Marginal accuracy was conducted using digital optical microscopy, while fracture resistance of the FPDs was tested using an electronic compressive strength measuring machine followed by SEM scanning to assess the effect of mode of fracture. Data were collected and statistically analyzed using the Aasistat 7.6. Variance was measured by the ANOVA test, using three different parameters namely, Ceramic type, measurement surface and abutment. Pair-wise Tukey's post-hoc tests were performed to detect significance between groups. Student ttest was done to detect significance between fracture mean values. P values ≤ 0.05 were considered to be statistically significant in all tests. Summary and Conclusion: Results showed that, the TZI group recorded lower vertical marginal gap than the veneered group regardless of the measurement surface or abutment teeth. The lingual surface recorded highest vertical marginal gap regardless of ceramic or abutment. The difference of vertical marginal gap between the two abutments was statistically non-significant regardless of ceramic group or measurement surface. Fracture load comparisons between both ceramic groups were statistically significant. Both groups were more or less similar to each other in regard to particle size and microscopic voids, when scanned for mode of fracture identification using SEM. The TZI bridges fracture showed more striations as is the case of fatigue, whereas an adhesive cohesive failure was noticed in veneered zirconia bridges at the veneering interface. Within the limitations of our experimental study (in vitro), the following can be concluded: 1. The TZI group shows better vertical marginal gap records than the veneered group. 2. The buccal surface showed the best vertical marginal gap recorded, followed by the proximal and the lingual surfaces. 3. Premolar and molar abutments showed no difference in the vertical marginal gap. 4. The fracture resistance of the TZI group showed higher resistance values than that of the veneered group