Diabetes mellitus (DM) alters carbohydrate and lipid metabolism to a great extent.This study was planned to determine whether infants of insulin dependent and gestational diabetic mothers and infants of gestational diabetic mothers have abnormal lipid metabolism. Two groups of newborns were included in the study; Group I:included 30 full terms, average for gestational age healthy neonates born to healthy mothers. Group II: Included 30 full term neonates of diabetic mothers, 9 of them were born to mothers with gestational diabetes GDM and the remaining 21 infants from insulin dependent diabetes mothers IDDMs.Cord blood samples were taken for measuring the blood glucose and lipid profile (cholesterol, triglycerides, LDL, HDL, Apo-A and Apo-B).The results showed that birth weight, the blood cholesterol level, LDL, HDL and Apo-A were significantly higher in IDMs than their control. Whereas triglycerides and Apo-B,cholesterol/HDL,LDL/HDL and Apo-B/Apo-A, showed non significant difference between the two groups. Moreover,HDL, Apo-A and were significantly higher in infants of gestational diabetes group than infants of insulin dependent diabetic mothers, Meanwhile, cholesterol/HDL was significantly higher in infants of IDDMs than in infants of GDMs,while other parameters did not differ significantly. In conclusion, diabetes in pregnant women causes a tendency to increase in the levels of lipid parameters in the offspring. These infants should be longitudinally followed up to assess whether this observation imposes an increased risk for atherosclerosis for advanced ages.