Systemic lupus erythematosus (SLE) is a multiorgan systemic autoimmune disorder of unknown aetiology, although several genetic factors affected by environmental agents affect the development of the disease, Numerous studies have tested the association between various candidate genes and susceptibility to SLE. knowing that It predominantly affects the females, this implies the important role of sex hormones such as estrogens in SLE pathogenesis. Estrogen acts via 2 receptors ESR and ESR Thus in this framework, the existence of ESR1and ESR2 variants may influence disease phenotypes, age of onset and clinical manifestations. As in numerous other research fields attempting to link genetic polymorphisms and different diseases, the large number of conflicting studies has led to a confusing picture. The discrepancies could represent differences in the genetic background between populations studied, which result in the multigene interactions with varying environmental factors and, in parallel, could be caused by problems such as small sample size.