Chronic liver diseases and cirrhosis are now being recognized as an important cause of morbidity and mortality world-wide Our goal was to assess the effect of variceal eradication either by endoscopic band ligation or injection sclerotherapy on platelet count.We found that Platelet count showed significant elevation in the third month compared to the initial reading in control group on B-blocker, while Platelet count showed no significance all over the 3 months period of follow up in group І & ІІ.Also follow up after one and Three months showed significant increase in portal vein diameter in group І (patients undergone band ligation), but in group ІІ (patients undergone injection sclerotherapy) there was significant decrease in portal vein diameter. While in Control groups no significant decrease. Follow up after one and Three months showed increase in splenic size in all patients, we compared within each group, there were significant increase in spleen size within patients of group ІІ (patients undergone injection sclerotherapy).