This thesis was designed to study and investigate the endocrine disrupture effect of fenpyroximate pesticide and the potentiality of each of alpha lipoic acid and N- acetylcysteine in attenuating the toxicity of fenpyroximate. 90 males of albino rats weighed(150gm) and (3 month age ) will be divided into nine 9 main groups (10 rats in each) according to type and dose that rats intake. Group (1) served as control, Group (2) rats were orally treated with antioxidant alpha lipoic acid (ALA), Group (3) rats were orally treated with antioxidant N-acetyl cysteine (NAC),Group (4) rats were orally treated with high dose of pesticide, Group (5) rats were orally treated with (ALA ) after administration of high dose of pesticide, Group (6) rats were orally treated with antioxidant (NAC) after administration of high dose of pesticide, Group( 7) rats were orally treated with low dose of pesticide , Group (8) rats were orally treated with antioxidant (ALA) after administration of low dose of pesticide , Group (9 ) rats were orally treated with antioxidant (NAC) after administration of low dose of pesticide . All groups were force fed by gastric intubation for 14 and 28 days. The oxidative stress status of treated animals has been evaluated by assessment of total ATPase , total antioxidant activity, SH-Protein and malondialdehyde (MDA), the thyroid function markers (T3, and T4 ), pancreatic function markers (amylase, lipase, insulin and glucose), in addition cholesterol and protein were measured . Our result revealed that fenpyroximate induce inhibitory effect on total antioxidant activity, SH-Protein activity and increased in lipid perioxidation (MDA). The results showed also disturbances in thyroid and pancreatic markers. In addition , our result revealed that natural antioxidants (ALA and NAC) have more or less counteracting effect on oxidative stress , endocrine toxicity caused by fenpyroximate.