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Comparison between cardiovascular changes in adults and children pre and post renal transplantation

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Internal Medicine

Advisors

El-Shabouni, Tareq M. , Muhammad, Husain H. , El-Khashab, Sahir O.

Authors

Muhammad, Eiman El-Sayed

Accessioned

2017-07-12 06:42:04

Available

2017-07-12 06:42:04

type

M.Sc. Thesis

Abstract

Backgroround : Cardiovascular diseases (CVD) are the principal causes of morbidity and mortality among adults and children with chronic kidney disease (CKD). After renal transplantation there is a substantial alteration in cardiac morphology and functions. Aim : The purpose of this study was to determine and to compare the effects of a successful renal transplantation on left ventricular (LV) morphology, systolic and diastolic function in children and adults.Material and methods: Echocardiography was done for 100 patients 30 renal transplant patients (<18years old) 30 renal transplant patients(>18years old)20 patients on regular hemodialysis(RHD) (<18years old) 20 patients on RHD(>18years old)Results: There was a statistically significant improvement in all cardiac parameters There was a regression in left ventricular end diastolic volume(LVED) both in children (4.7 ± 0.8 to 4.2 ± 0.5) and in adults (5.9 ± 0.7to 4.9 ± 0.6) There was a regression in left ventricular end systolic volume (LVES) both in children( 3.1 ± 0.6 to 2.4 ± 0.4) and in adults (4.1 ± 0.9 to 3.1 ± 0.5) There was an improvement in fractional shortening (FS) both in children(32.6 ± 5.3 to 41.7 ± 7.6) and adults(29.0 ± 6.6 to 36.5 ± 4.1). Although the improvement in EF (59.7 ± 7.0 to 71.9 ± 6.1) was higher in children yet the degree of improvement in children (12.2 ± 5.1) when compared to the degree of improvement in adults(12.7 ± 9.8) did not show statistical difference.Conclusion: From these observations, we concluded that cardiac morphological parameters improve in the early posttransplant period. Improvements in renal function, anemia status showed strong associations with these changes. Renal transplantation improves cardiac morphology and function and should be done as early as possible to attain the optimum improvement.

Issued

1 Jan 2010

DOI

http://dx.doi.org/10.21473/iknito-space/37499

Details

Type

Thesis

Created At

05 Feb 2023