As VEGF is involved in the process of new blood vessel formation,It seems to be a potential candidate gene for DR. the 5' UTR, promoter region of VEGF has been shown to be highly polymorphic. In our study we analyzed the VEGF –634 C/G polymorphism as a potential genetic marker of DR.There were significant differences in high density lipoprotein (HDL) cholesterol and hemoglobin A1c between diabetic groups. The CG and GG genotype was significantly higher in the DR group compared with the DWR group, also when compared with healthy control group. The CC genotype was significantly lower in the DR group when compared with the DWR group, also when compared with healthy control group. The –634 C/G polymorphism might serve as a predictive factor for the development of diabetic retinopathy.