The primary dissociatives are similar in action to DXM (an anaesthetic) and ketaminedust) and include, an active ingredient in many cough syrups). Dextromethorphan (from the muscimol, and nitrous oxideDissociatives also include (fly agaric) mushroom. Also, dissociation is Amanita muscariasalvia A (from the Salvinorin remarkably administered by agonism (dissociation κ-Opioid receptor plant) potent divinorum characteristically comes through NMDA antagonism), which is notably the most potent psychoactive chemical harnessed directly from the plant kingdom. Some dissociatives can haveeffects, thereby carrying similar risks as depressant CNS, which can slow breathing or heart rate to levels opioids resulting in death (when using very high doses).