The aim of this study is the assessment of depression and anxiety in patients with chronic obstructive pulmonary disease, and to examine the impact of anxiety and depressive symptoms on psychological and physical functioning. Subjects and methods: Sixty male patients with COPD recruited from the chest department of Beni Seuf university hospital, divided according to spirometric classification of COPD severity based on post-bronchodilator FEV1 to four groups. They were subjected to standardized measure of present state examination test, Beck Depression Inventory, Beck Anxiety Inventory, Rating Scales for Psychopathological Health status and Quality of Life Scale and St. George’s Respiratory Questionnaire. Results: Findings of the study reported that there is high frequency of psychiatric co-morbidities in COPD patients especially anxiety and depression which represents the most frequent psychiatric disorder in COPD. The presence of psychiatric co-morbidities increase the impairment in quality of life in COPD patients.