Background: Dual source multislice CT is a recent development in the spiral CT that allows ECG-gated complete coronary coverage in a reasonable time. Objectives: To evaluate the accuracy of dual source 64-CT coronary angiography in assessment of coronary arteries. Conventional coronary angiography has been used as a gold standard for comparison. Methods: A total number of 50 patients (with 80% of them with intermediate likelihood of CAD) were enrolled for dual source 64-CT coronary angiography. Conventional coronay angiography to all patients has been performed within one month of MSCT. Findings of MSCT coronay angiography were been compared to those of conventional angiograms. Evaluation was been performed on a per segment basis. using the results of conventional CA as the gold standard.Results: Our study revealed an overall sensitivity, specificity, PPV and NPV of 93%, 92%, 72% and 98% respectively with a diagnostic accuracy of 91% for detection of significant coronary stenosis (≥ 50%) or occlusion. Conclusion: Dual Source-MSCT coronary angiography is a very helpful test in diagnosing patients with coronary artery disease when compared to conventional CA (at higher heart rates and less radiation doses when compared to sinle source 64-CT). Dual source-MSCT-CA can rule out presence of significant CAD in patients with intermediate likelihood of CAD.