Background: Insulin resistance and high insulin level could have a pathophysiologic implication in migraine. Moreover, a role for insulin resistance in the comorbidity between migraine and vascular diseases has been suggested.Objective: The main aim was to verify whether migraineurs have abnormalities of the glucose and insulin metabolism. A secondary aim was to search for a correlation between these metabolic indices and headache characteristics.Patients and methods: 20 non -diabetic, non -obese and normotensive migraineurs and 15 healthy volunteers, age and body mass index (BMI) matched, were included. All patients underwent general, neurological and radiological assessment. After a 12-hour fast and 2-hour after glucose loading, serum glucose and insulin were measured and insulin resistance Homeostasis Model Assessment insulin resistance (HOMA-IR) and McAuley insulin sensitivity indices were calculated for all participants.Results: A significant difference between patients and control subjects for fasting glucose level (P = 0.011) was detected. A statistically significant positive correlations were found between age of the patients at disease onset and fasting serum insulin (P- value = 0.002), (HOMA-IR index) (P- value = 0.002), triglyceride level (P- value = 0.01) and low density lipoprotein (P- value = 0.03) in addition to inverse correlation between the age at disease onset and McAuley insulin sensitivity index (P- value = 0.001). Other disease characteristics (headache frequency and duration) were not significantly correlated with any of the studied metabolic indices.Conclusions: Impaired fasting glycaemia may be comorbidity in migraineurs. Patients with higher age at disease onset are more likely to be insulin resistant. The interaction between the two conditions is complex and warrants further studies.