Blood stream infections (BSI) in recent years were considered one of major problems to public health all over the world. Our study aimed to establish the clinical and microbiological characteristics of bloodstream infections for patients who were admitted to Police Hospital el Agoza, Cairo, Egypt, in order to guide toward measures to reduce the incidence of mortality due to bloodstream infection. This study resulted that the most frequently isolated organisms from blood cultures were Gram positive cocci 52%, Staphylococci aureus represented the commonest isolated organisms. ICU represented 58% from studied cases of bacteremia. The predisposing factors for BSI were diabetes mellitus (DM), neurological affection (paralysis), aging, renal insufficient, pancytopenia, cancer, orthopedic fracture and hospital acquired infections. Chest infection (pneumoniae) were the commonest infection associated with bacteremia that might be represent the source of infection. In our study, mortality rate due to BSI was 46 %. The mortality rate among blood culture positive patients admitted in all ICUs were 62%.