The aim of this work is to review the aetiology, pathogenesis, clinical picture and management of hereditary disorders. Hereditary retinal detachment is a separation of sensory retina from retinal pigment epithelium due to hereditary disorders that either primarily caused retinal detachment or leads to secondary retinal detachment. Hereditary retinal detachment may be rhegmatogenous, tractional and/or exudative. Hereditary rhegmatogenous retinal detachment is the commonest type and caused by retinal break which permits sub-retinal fluid to gain access to subretinal space. Hereditary disorders associated with rhegmatogenous retinal detachment include : Stickler syndrome, Marfan syndrome, Ehler’s Danlos syndrome, X-linked juvenile retinoschisis, Goldmann Favre vitreo-retinal degeneration, Homocystinuria. Morning glory disc anomaly, Opitc nervehead coloboma and Infero-temporal dialysis. Tractional retinal detachment is due to separation of sensory retina from retinal pigment epithelium. Hereditary disorders associated with tractional retinal detachment include : Diabetes mellitus, Sickle cell anemia, Falciform detachment, Norrie disease, Incontinenti pigmenti and Familial exudative vitreo-retinopathies. Hereditary exudative retinal detachment is the least common form and caused by retinal pigment epithelial damage. Hereditary disorders associated with exudative retinal detachment include : Alport syndrome, Von Hippel Lindau disease, Retinoblastoma and Optic nerve head pits. Recent application of molecular genetic technology to the study of a variety of hereditary-vitreo-retinal disorders have increased our abilities to identify and localize either the abnormal gene or a DNA marker that is closely linked to the gene responsible for specific ocular disease.