The incidence of coronary artery disease (CAD) has increased in Egypt. We conducted this study to determine the data of CAD patients at our hospital, and to identify the prevalence of conventional risk factors of CAD and their effects on the severity of underlying coronary lesions.Object of the study: To know the demographic, clinical, and angiographic features of patients who underwent coronary angiography or Percutanouescoronary interventions at our hospitals.Methodology:It is a retrospective study where records of 1700 patients who had undergone coronary angiography and Percutanoues coronary intervention between 2006 and 2008, were analyzed. Demographic features, clinical data, risk factors and angiographic profile, were studied.Summary of results: Mean age of the patients was 53.84 ± 9.5 (from ≤45 - >65 year). 73.6% were males and the rest (26.4%) were females. About 37.2% of patients had documented risk factors profile, in which diabetes mellitus(55.5%),hypertension(47,4%)were the most common risk factors , followed by smoking(26.5%), dyslipidemia (8.8%),family history of CAD(5.6%)and obesity(0.7%). Fifty patient had no any conventional risk factors for CAD.Unstable angina and STEMI were most common indications for coronary catheterization. 74.5% of patients underwent only diagnosticcoronary angiography, 25.5% had PCI. 185 patient (10.9%) had previousPCI and 69 patient (4.1%)with history of previous CABG. SVD (21.5%) was more prevalent than double vessel disease(19.1%),MVD(39.5%). LAD (62%) was the commonest to be involved followed by RCA (37.7%) and LCX (22.7%). Normal coronary angiogram was noted in 20% of patients .In stent restenosis was in 89 case (48%)of patients with previous PCI. Patients with previous CABG had (46.3%)SVG stenosis and (18.8%) LIMA stenosis. Coronary thrombosis was in 3.6% and mainly in RCA. Ectasia was in 7.2% of patients, it prevalent in SVD (5.1%), in DVD 1.2% and in triple vessels in 0.8%. RCA was the most common artery affected by ectasia. 20.9% of patients referred for urgent CABG, 13.1% for PCI and 34.7% of patients to be continuous on aggressive medical treatment.Conclusion: Results from our series confirm the multifactorial nature of coronary artery disease. Multivessel disease are highly distributed among Egyptians. Early detection of coronary artery disease risk factors and coronary anatomy are mandatory for a successful therapeutic strategy. PCI is a safe procedure even in the setting of acute coronary syndromes.