Objective: To establish age-specific and location specific reference values for urinary calcium to creatinine ratio (UCa/Cr) for Egyptian children.Subjects and Methods: This study included 100 apparently healthy Egyptian children (52 boys and 48 girls) aged 3-12 years from Beni Suef and Cairo Governorates. They were clinically examined and those with abnormal clinical findings were excluded. Each child was asked to provide a random urine sample for which 1-2 mL of 6 molar HCl were added. Samples were mixed and left for one hour prior to chemical analysis for calcium (Ca) and creatinine (Cr). Urinary levels of Ca were divided by those of urinary Cr levels to obtain UCa/Cr.Results: Mean urinary Ca level was 5.89±4.30 mg while the urinary Cr level was 69.83±40.25 mg and UCa/Cr was 0.1135±0.1189. UCa/Cr is negatively correlated with age (r=-0.200, p=0.047), weight (r=-0.209, p=0.307), height (r=-0.210, p=0.036) and body mass index (r=-0.201, p=0.042). Urinary Ca was higher among males than females while urinary Cr was higher among females than males. UCa/Cr was higher among males than females. UCa/Cr was significantly less among older children than younger children (0.0885±0.0670 vs. 0.1466±0.1593, respectively, p=0.015). UCa/Cr was significantly higher among children from Beni Suef than those from Cairo (p=0.011). Conclusions: UCa/Cr is different from one location to another and from one age group to another. Within Egypt, there are differences in UCa/Cr between one governorate to another. Ratios for children in Beni Suef are significantly higher than those for children in Cairo. Boys have higher UCa/Cr than girls. UCa/Cr decreases as the child grows older. Body mass index is also significantly correlated with urinary UCa/Cr.Recommendations: To expand the current research in a national study that covers all governorates of Egypt to identify the normal values for UCa/Cr in various age groups of children; to follow up children with high UCa/Cr for early detection of any urinary problems; and to conduct epidemiological studies to explain differences in levels of urinary Ca excretion and UCa/Cr among Egyptian children in different governorates.