Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder. IBS has no objective clinical endpoints; so measuring the health related quality of life (HRQOL) is very important in detecting progress pattern.Our study aimed at exploring the pattern of IBS patients and detecting the impact of IBS on their HRQOL in the primary care practice.Our study is conducted over 100 IBS patients. Diagnosis based on the Rome Ш criteria for IBS, the irritable bowel syndrome quality of life questionnaire (IBS-QOL) and the work productivity and activity impairment questionnaire (WPAI:IBS) was used to measure both the impact of IBS on HRQOL and on the work and activity for IBS patients and to detect the severity of abdominal pain visual analogue scale (VAS) was used.Our study found that mean HRQOL in IBS patients was 45.9. The mean absenteeism was 6.8%, the mean degree of work impairment (presenteeism) was 34% while the mean percent overall work productivity loss was 37.9%, the daily activity impairment was 46.4% and the mean severity of abdominal pain was 6.2.Our study concluded that irritable bowel syndrome greatly affects the health quality of life, work productivity and daily activity.