Background: Colorectal cancer is one of the leading causes of cancer death in both developed and developing nations. It is the third most common type of cancer worldwide.Aim of the work: Evaluation of the immunohistochemical expression of galectin-3 in cases of colorectal carcinoma & correlation between galectin-3 expression and other clinical and pathological features.Material and Methods: The current study included sixty cases of colorectal carcinomas collected from the Pathology department, Faculty of medicine, Cairo University during the period from January 2011 till March 2013, studied histologically and immunohistochemically for galectin-3 expression. Results: Galectin-3 expression was positive in 81.7% of total colorectal carcinoma studied cases. There was no statistical relationship detected between galectin-3 expression regarding age, sex, tumor gross pattern, tumor size, the depth of tumor invasion, lymph node metastasis, distant metastasis and vascular invasion. Statistically significant relationships were detected between galectin-3 expression regarding the followings the tumor site (rectum predominating; P value=0.038), the histological type where 89.8% of conventional adenocarcinoma cases were galectin-3 positive while 63.6% of mucoid adenocarcinoma cases were galectin-3 negative (P value <0.001), the histological grade where 100% of grade I, 93.75% of grade II and 57.2% of grade III were galectin-3 expression positive (P value=0.002), and modified Dukes' stage where 98% of positive galectin-3 expression cases were modified Dukes' stage B&C each was 49% (P value=0.01789).Conclusion and Recommendations: Therefore, it is suggested that galectin-3 may be used as a prognostic marker to predict poor outcome of patients with colorectal carcinomas and it will be necessary to carry out similar studies on a larger sample size, scoring system for galectin-3 expression can be applied and searching for correlation between galectin-3 expression and survival rate.