Today, we are in a position to image the entire body with a single MRI examination. This is largely attributable to the enormous technical progress in the field of MRI technology. Various indications for whole-body MRI – both oncological and non-oncological – have already been clinically evaluated. For instance, whole-body MRI can be deployed for patients with bone metastases as an alternative to the standard of reference, bone scintigraphy or in comparison with FDG-PET. Additional potential indications are the imaging of muscular involvement in patients with polymyositis and whole-body fat measurement by means of MRI to determine body composition. Also whole-body MR angiography has already made advances in routine diagnostics, on account of atherosclerosis being a widespread disease thus requiring extensive diagnostic attention.