Hepatocellular carcinoma (HCC) is the third largest cause of cancerdeaths worldwide and chronic HCV infection is considered one of the mostimportant risk factor for HCC, representing about 25% of HCC cases.The early detection of Hepatocellular carcinoma in an at-riskpopulation is the only hope to provide the effective treatment and to reducethe death rate. Many trials were done to use new screening serum markersinstead of serum level of alpha-fetoprotein which are commonly used incombination with abdominal ultrasonography, because it is associated withhigh rate of both false positive and negative results.In this study, genetic differences of IFN-receptor gene family (IFN-1,IFN-3 and IFN-7) was studied in hepatitis C cirrhotic patients who developedhepatocellular carcinoma from those who did not and we used the expressionprofile of IFN-receptor gene family to detect HCC as early as possible whilescreening hepatitis C cirrhotic patients.