Immune thrombocytopenic purpura (ITP) is one of the most common autoimmune diseases characterized by low platelet count <150 X109/L of unknown etiology. We reviewed the medical records of the Hematology Outpatient Clinic, New Children's Hospital Cairo University of all patients diagnosed as ITP over the past 10 years. We studied their demographic data as age and sex; age at presentation and presenting manifestations whether skin and/or mucous membrane bleeds as well as initial and follow-up platelet counts. We further assessed the treatment they received, their response to it, the course of the illness whether acute or chronic and complications of both the disease and therapy.