Background: Chronic kidney disease (CKD) is a public health problem worldwide. The most common risk factors for CKD include type 2 diabetes mellitus, hypertension, cardiovascular disease, family history of CKD, and age >60 years. Progress to kidney failure could be prevented by screening and early treatment of CKD. Objectives: To detect the prevalence of stages of CKD among patients attending outpatient clinics in Sohag University Hospital and to compare between prevalence of CKD in Diabetic, non Diabetic patients and patients with recurrent urinary tract infection (RUTI).Methodology: It is a cross sectional descriptive study done in the period From March 2012 to June 2012, 150 subjects were selected by a purposive sampling method, from patients attending the internal medicine outpatient clinics in Sohag University Hospital. They were ≥40 years; they were divided into 3 groups : Group I (diabetic group): They were 50 patients, having type 2 DM ; Group II: 50 non diabetic patients having personal history of RUTI ; Group III (the control group): 50 healthy subjects without DM, hypertension and without UTI. They were subjected to: a screening questionnaire to collect information about medical history, demographic characteristics and risk factors for CKD, clinical examination and laboratory investigations including blood sugar, Serum creatinine (S.Cr), Hb A1c, urine analysis and albumin creatinine ratio. Results: The prevalence of CKD (eGFR< 60) depending on the MDRD method equals 16%, was significant for Group I and group ΙΙ in comparison with group ΙΙΙ. The prevalence of Stage 1 was (25%), Stage 2 (20.5%), Stage 3 (34%), and Stage 4 (20.5%). Conclusion: We conclude that CKD shows high prevalence in Sohag governorate; diabetics and patients with RUTI are at high risk groups in need for regular screening program.