Different ablation profiles are designed in attempts to achieve a perfect optical system. In a summary of types of ablation profiles in corneal laser surgery, treatments were divided into those based on the total optical system (the classic Munnerlyn’s formula, wavefront-guided profiles, and wavefront- optimized profiles), and those based on the cornea (topography- guided profiles and aspheric/Q-factor-adjusted profiles). Some studies have compared different with variable results. Differences in inclusion criteria, study design, laser platforms, and surgeon variables may explain the varied results. In general, the change in postoperative HOAs after customized or optimized ablations is less than that for conventional, due to treatment of preexisting HOAs and/or less induction of new HOAs. All ablation profiles including the conventional are of good, we cannot, hence choose one as the universal perfect, otherwise, based on the great variability between individuals, in the eye as an optical system and in the visual requirements and expectations from refractive surgeries, we can choose the ablation profile suiting each individual according to his eye’s nature and visual needs.