Diabetes mellitus is a major health problem and the vast majority of morbidity, mortality and costs are related to the long-term vascular complications.In this work, we aimed to study circulating insulin-like growth factor-I in thirty-one type-2 diabetic patients and nine age matched control group, also the influence of microvascular complications, glycemic control, age, sex, duration of diabetes and type of treatment on its concentration.Serum insulin-like growth factor-I was found to be significantly lower in type-2 diabetic patients than in controls and also significantly lower in females than in males. Insulin-like growth factor-I was not found to be affected by the duration of diabetes or type of treatment. There was a negative correlation between insulin-like growth factor-I and microalbuminuria, fasting blood sugar, postprandial blood sugar and glycosylated hemoglobin A1c.It had been postulated that premature decline in serum insulin-like growth factor-I in type-2 diabetics, especially in those with poor glycemic control may result in progression of diabetic microvascular complications.