Homogenous assays for measuring HDL-C and LDL-C were more precise and accurate than the other assay methods namely precipitation and electrophoresis. They had the lowest TE% among the other assay techniques. Their measuring ranges covered most of the commonly encountered clinical specimens. They were not interfered by bilirubin, haemoglobin, or triglycerides up to an acceptable degree. The development of new ultracentrifugation machines will reduce the ultracentrifugation time to make this method used routinely in the future.