The reasons for hemodynamic dysfunction in the period of weaning from CPB are multifactorial. The balance between maintaining a satisfactory blood pressure together with an appropriate degree of afterload reduction remains a goal for the anesthesiologist. The conventional use an adrenergic agonist combined with nitrates has been well established in managing patients with ventricular dysfunction. However, the exacerbation of tachycardia that may accompany this maneuver with the potential of aggravating ventricular ischemia and dysfunction must be taken into consideration. Compared to the conventional use of adrenergic agonists and nitrates, milrinone proved to be an efficient agent for weaning of patients with ventricular dysfunction from CPB. Statistically significant values, P < 0.01, were obtained as regards cardiac output, cardiac index, fractional area of contraction, and stroke volume index. The term inodilator well describes the effects of milrinone; while better cardiac indices where obtained at all times, the vasodilation produced necessitated the use of vasopressors, and volume transfusion to keep a normovolemic state.