This study compares histology, Ki-67/MIB-1 proliferation indices (PI) as cell proliferation marker and Bcl-2 indices as anti-apoptotic marker in 80 benign, atypical, and anaplastic (malignant) meningioma cases, according to the WHO 2000 classification. Histologic parameters, including loss of architecture (sheeting), cellularity, cellular pleomorphism, prominent nucleoli (macronucleoli), mitoses, atypical mitoses, nuclear atypia, necrosis, small cell formation, brain invasion, dural invasion, and bone invasion were assessed in each case. Fifty cases, 24, and 6 cases were classified as benign, atypical, and anaplastic meningiomas, respectively. Significant differences were found between the three meningioma groups as regards architectural sheeting, cellularity, cellular pleomorphism, macronucleoli, necrosis, mitotic figures, nuclear atypia, and brain invasion (p = 0.0001). Mean Ki-67/MIB-1 PI for the benign, atypical, and anaplastic groups were 1.07%, 6.42%, and 14.17%, respectively. The correlation between increasing grades of meningiomas, Ki-67/MIB-1 labelling indices was statistically significant. While, Bcl-2 was found to be of limited value in meningioma assessment.