Objective: to assess the benefit of using NIM2-XL for INM of RLN during thyroidectomy, facial nerve during parotidectomy and spinal accessory nerve during SLND. Patients and Methods: 24 patients classified as 3 groups, group I included 15 patients underwent thyroidectomy with INM of the RLN, group II included 6 patients underwent superficial parotidectomy with INM of the facial nerve and group III included 3 patients underwent SLND with INM of the spinal accessory nerve. Results: the rate of success of INM of group I was 86.6 %, while the rate of failure of INM of group I was 13.3% and the rate of success of INM of group II & III was 100 %. Conclusions: the results suggest that INM using (NIM2-XL) reduces the incidence of iatrogenic nerve injury