Ischemic stroke is one of the most common causes of death worldwide and it is most often caused by thrombotic process. C-reactive protein and homocysteine have been associated with underlying inflammatory process of atherosclerosis. We investigated the level of high sensitivity CRP and homocysteine during acute period of ischemic stroke in diabetic and non diabetic patients and evaluated relationship between their levels and other risk factors levels. homocysteine and hs CRP were measured in 50 patients with acute stroke and 5 healthy controls. Patients were classified into three groups , Group ( I ) which included Patients who are not diabetic and have acute ischemic stroke ; they were 25 patients . Group (II ) which included Diabetic patients with acute ischemic stroke . It included 25 patients and Group (III ) It included 5 normal subjects. Overall 80% of our patients had elevated levels of hs CRP and mean hs CRP level of our patients was elevated and it was significantly higher than in controls (P= 0.001). Only 26% of patients had elevated homocysteine level and mean homocysteine level was normal and not significantly different from controls (P=0.35). No difference was found between diabetic and non diabetic patients in levels of hs CRP and homocysteine. Conclusion: Elevated levels of hs CRP could be considered as a risk factor for acute ischemic stroke but it is difficult to consider homocysteine as so according to our results.