Aim: To assess improved apoptotic process in diabetic rats treated with PDE-5 Is and/or T. Materials and Methods: One hundred and sixty five aged male Sprague Dawley rats (200-250 gm) were divided into; controls, STZ- induced diabetic rats, diabetic rats on sildenafil day after day (2 mg/kg & 4 mg/kg), diabetic rats on 22.5 mg/kg IM T once, diabetic rats on sildenafil and T (2 mg/kg & 4 mg/kg), diabetic rats on 0.45 mg/kg tadalafil day after day, diabetic rats on tadalafil and T, diabetic rats on sildenafil and tadalafil and diabetic rats on sildenafil, tadalafil and T. In dissected cavernous tissues (after 4 weeks) gene expression of iNOS, BAX & Bcl2 was done and MDA, GPx, cGMP were estimated.Results: Cavernous tissues of diabetic rats showed significant decrease in iNOS, cGMP, Bcl2, GPx and significant increase in BAX, MDA compared with the controls. Diabetic rats on sildenafil or tadalafil intake showed significant increase in iNOS, cGMP, Bcl2, GPx and significant decrease in BAX, MDA compared with diabetics. Diabetic rats on T alone showed significant increase in cGMP, Bcl2, GPx and significant decrease in BAX, MDA compared with diabetics. Diabetic rats on sildenafil & T or tadalafil & T showed significant improvement in tested parameters compared with diabetics or diabetic on PDE-5Is alone. Diabetic rats on sildenafil & tadalafil with or without T showed significant improvement of in tested parameters compared with other groups.Conclusion: PDE-5Is and T have an anti-apoptotic cavernous tissue effect separately or combined.