Osteoporosis, a disease characterized by high bone turnover, is almost the most frequent degenerative disease in modern world. Evidence that leptin regulates bone turnover in part through a central nervous system / adrenergic system relay has driven attention towards the importance of adrenergic stimulation and blockade in osteoporosis. Beta2- adrenergic receptor-mediated signaling in osteoblasts inhibits bone formation and triggers receptor activator of nuclear factor Kappa B ligand (RANKL) mass- mediated osteoclastogenesis and bone resorption. In this study, we intended to study the deleterious effect of doping dose of salbutamol (4mg/kg/day 5days/week for six weeks) on bone, as a model of osteoporosis, compared to the ovariectomy- induced bone loss. We also studied the possible preventive and therapeutic effects of both propranolol (1mg/kg/day 5days/week) and atenolol (1mg/kg/day 5days/week) on these two models. We classified our mature female albino rats into three groups: a control group, ovariectomized group in which proranolol or atenolol treatment were started either simultaneously with bilateral ovariectomy for two weeks or started two weeks after surgery for ten weeks and a six weeks salbutamol- treated group in which proranolol or atenolol treatment were started either simultaneously or six weeks after salbutamol for ten weeks. Effects of ovariectomy and salbutamol on bone and the possible modulatory effect of propranolol and atenolol were assessed by measuring the level of bone- specific alkaline phosphatase- BSALP (a bone formation marker), tartrate- resistant acid phosphates- TRAP and 24- hours urinary calcium (two bone resorption markers). Also femoral bone histomorphometric analysis for detection of changes in bone micro- structure was done. Bilateral ovariectomy led to osteoporosis detected two weeks after surgery and worsens at the 12th week thereafter; while, salbutamol treatment for six weeks induced osteoporosis in rats that was partially recovered after stoppage of the drug for ten weeks but still some osteoporotic changes were evident. Propranolol treatment showed significant preventive and therapeutic effects on both models of osteoporosis; while atenolol treatment led to more bone loss.