Antioxidants are the world’s most widely used pharmaceutical products to overcome the different diseases which are caused by free radicals that result from the contineous oxidation processes in the body.This study were done to reveal the toxic effects of vitamins A & E and to investigate the protective role of both vitamins on carbon tetrachloride induced toxicity. Oral toxic doses were given to the albino rats for 3 months. Kidney & liver function tests, products of lipid peroxidation & histopathology of liver & kidney were done. Vitamin A was the most toxic & vitamin E was less toxic.Both vitamins exerts a protective effect against the toxic effects produced by CCL4. However the protection was more with vitamin E than with vitamin A.