Cytokines especially interleukin –6 appear to play an important role in development of congestive heart failure. Interleukin-6 multifunctional proinflammatory and vasodepressor cytokine mediate both immune and inflammatory response. In this study, IL-6 level showed a statistically significant elevation in cases suffering from CHF whit various etiologies.IL-6 level is a promising marker in the diagnosis, assessment of severity, course, prognosis and treatment in CHF.