Purpose: Determine the early and intermediate - term results of angioplasty with adjunctive stenting for lower extremities peripheral arterial occlusive disease , to compare iliac versus infrainguinal arterial intervention and to assess the prognostic value of high sensitivity CRP and intermediate–term outcome.Patients and methods: The study enrolled 48 patients who underwent PTA and stenting 55 limbs. The indications for intervention were severe claudication in 54.5% and chronic CLI in 25 45.5% of limbs. Lesions were iliac in 51% and femoropopliteal in 49% of limbs. Stenting was carried out in 39 limbs and PTA alone in 16 limbs. Follow up period ranged between 6 and 24 months with a mean of (11.1±5.6) months. Results: Angiographic, haemodynamic and procedural success were achieved in 98.2%, 96.4% and 96.4%limbs respectively. Six month primary and secondary patency rates were 88% and 94% respectively. Significant predictors of restenosis included young age (52.7±7 vs. 59.5±9.5. p =0.039 with a cutoff point of 54 years), TASC type C lesion (45.5% restenosis in type C lesions versus 12.8 % restenosis in lesions type A and B, P= 0.017) and post interventionl residual diameter stenosis (19.6%±6.2% versus 12.1%±7.6%, p=0.006 with a cutoff point at 12.5%). Stenting was performed more frequently in the aortoiliac segment than the FP segment (89.6% versus 46.4%, p= 0.001). Lesions of the FP segments were associated with higher incidence of restenosis at 6 and 12 months than lesions in the aortoiliac segments (24% and 32% versus 0% and 7.2%, p values 0.009 and 0.039 respectively). Post procedural levels of hs-CRP were significant predictors of restenosis (26.3 ± 14.8 versus 12.8 ± 8.9, p= 0.007). Lower levels of post procedural hs-CRP (13.4 ± 9.2 versus 26.1 ± 16.2, p =0.018) of sustained clinical improvement during follow up.Conclusions: PTA and adjunctive stenting for lower extremity obstructive lesions shows a high procedural success rates with good intermediate term outcome. FP lesions are associated with higher incidence of restenosis at 6 and 12 months than iliac lesions Post procedural levels of hs-CRP can predict restenosis and future clinical outcome.