Objective: Nephritis is known as the most serious complication of systemic lupus erythematosus and the strongest predictor of poor outcome. The varied and unpredictable nature of lupus nephritis and the risks associated with its treatment have challenged investigators to seek the variables with which to identify patients who are likely to have worse outcome and thus need the most aggressive therapy.Methods: The study included 30 patients with juvenile SLE with a male to female ratio of 1:3.2. All patients were subjected to 2 renal biopsies with a minimum observation period of 10 months. The study group was divided according to the results of the 2 renal biopsies into 2 groups: group I: patients with favorable outcome, group II: patients with unfavorable outcome. Results: Transformation from one WHO class to another was observed in 70% of patients. Fifteen patients showed regression of renal disease (either decrease in the histologic class or regression of pathology within the same class) and the other 15 showed progression of renal disease (either increase in the histologic class or progression of pathology within the same class). The various clinical, laboratory and pathological variables were contrasted with the outcome to define those associated with a poor outcome.Conclusion: It was found that delayed remission of nephrotic syndrome, high serum creatinine, low hematocrit, increased 24 hours urinary protein excretion and incompliance to treatment are the statistically significant factors that can predict a poor renal outcome.