Unexplained RM accounts for about 50% of the cases of recurrent miscarriage. The study examined the correlation and prevalence of TNF-α and ACA in Egyptian women; with history of unexplained recurrent miscarriage. There was an association between the presence of ACA and unexplained RM, and a highly significant positive correlation between the number of previous miscarriages; and the frequency of ACA IgG positivity was detected. There is no association between TNF-α and unexplained RM.