Infective endocarditis (IE) is associated with substantial morbidity and mortality, the infecting organism may be bacterial or fungal. Embolic events (EE) in infective endocarditis remain a common and severe complication with the majority as cerebral emboli, the occurrence of EE is associated with a higher mortality. The risk of EE increases with staphylococcal , enterococcal and fungal infection and increase in the size of vegetations, an increase in C-reactive protein (CRP), increase in E-selectin and P-selectin, endothelial and platelet activation, an increase in antiphospholipid antibodies (APA), previous embolism, and with native mitral valve infection as compared to aortic valve infection. Thus, EE can be prevented by early administration of antibiotics, and early valve replacement.