Diabetic neuropathy is one of the most common complication associated with diabetes. It appears to be more common in people who have problems controlling their blood glucose levels in those with high levels of blood lipids and blood pressure. Diabetic neuropathies are a family of nerve disorders caused by diabetes. People with diabetes can over time have damage to nerves throughout the body affecting the peripheral nerves and may also occur in every organ system, including the digestive tract, hart and sex people with diabetes can develop nerve problems at any time but the longer the duration of diabetes the greater the risk.This study was conducted 20 patients on 2 groups of diabetic patients, 10 patients with peripheral neuropathy and 10 patients without peripheral neuropathy and 10 control group and 10 healthy persons subjects control group. All patients and control were subjected to the following full clinical examinations, fasting and postprandial blood sugar, nerve conduction study and laser Doppler fluximetry. In this study, there was no statistical significant difference between diabetes without neuropathy and control group as regard the duplex parameters, the effect of heat and the flow of blood (P > 0. 05) and this denoting that the thermo regulatory function in diabetic group without peripheral neuropathy is intact. On the other hand, there was statistically significant different between diabetic neuropathy group compared to control group as regard N.C.L and N.C.V (P = 0.01). the basal duplex parameter of flow in the foot microcirculation were higher in control group than diabetic neuropathy group but this was not statistically significant (P < 0.05). While after applying temperature there was decrease of the slope and decrease in maximal flow in diabetic neuropathy group as compared to control (P < 0.005).This means that there was deficient vasodilatation of foot microcirculation in diabetic patient with type 2diabetes with neuropathy under the effect of heat exposure denoting impaired thermo regulatory control function. In this study diabetic neuropathy group show reduced blood flow in foot microcirculation after exposure to temperature as compared to diabetic without neuropathy group as shown by decrease the mean flow (62 Vs 48 in diabetic +ve), decrease maximal flow (89Vs 46) in diabetic neuropathy, minimal flow (46vs35) in diabetic neuropathy group (P< 0.01) and the percent of change in blood flow before and after thermal stimulation was significantly higher in diabetic without neuropathy group than diabetic neuropathy group (283 Vs 162.50) (P= 0.006). We conclude that poly neuropathy in type 2 diabetes may be related to the duration of diabetes and it causes defective thermo regulatory response of foot microcirculation to heat and leading to impaired vasodilatation response causing decreased capillary blood flow and may participate in foot ulceration.