Immunosuppressive effect of blood transfusion causes a Downregulation of the immune system, with a number of immunologicParameters being downregulated . This finding has caused growing attention as to whether this has an adverse effect on patiens receiving blood transfusion . A large number of articles have been published, both pro and con, addressing the issues of whether blood transfusion is associated with an increased frequency of tumour recurrence following tumour resection or with a higher incidence postoperative infection following surgery . some physicians are recommendingleukocytes reduction of all blood products suggesting that the leukocytes are involed in downregulation of the immune system. Removal of the leukocytes might be beneficial in preventing these Potential complication .