Acute leukaemia is a haematologic malignant disorder characterized by the uncontrolled proliferation of haematopoietic cells causing progressive infilteration of bone marrow with immature cells.A key issue in the treatment of acute leukaemia is the development of resistance to chemotherapeutic drugs leading to treatment failure and death. Several mechanisms may account for this phenomenon by which tumor cells become drug resistant including expression of lung resistance protein (LRP) gene.LRP is a cytoplasmic protein with molecular weight of 110 KD and it is though to be involved in the cytoplasmic sequestration of drugs. LRP expression appeared to be a poor prognostic factor in predicting refractoriness in some patients with acute leukaemia.In this study we investigated for the presence of LRP gene in 25 patients with de novo acute leukaemia using reverse transcriptase polymerase chain reaction (RT-PCR) we found that 4 out of 8 AML patients and 3 out of 17 ALL patients are positive for LRP gene. LRP expression in these patients was associated with inferior response to chemotherapy and can be used as prognostic factor for acute leukaemia and thus may be helpful in determining chemotherapeutic protocols for patients with acute leukaemia.