Carcinoma of the colon and rectum is the second most common neoplasm in both sexes seen in the developed countries and represents the third most important cause of cancer mortality in the world.Epidemiologic studies have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs); known to inhibit cyclooxygenase (Cox), reduce the risk of colorectal cancer. Many studies have suggested that an increase in the expression of cyclooxygenase (COX-2), a key –inducible enzyme involved in the production of prostaglandins and other eico-sanoids, may play a significant role in carcinogenesis in addition to its well-known role in inflammatory reactions.