This study aimed to evaluate number of biochemical markers aspredictors of clinically significant fibrosis in 56 patients with chronicHCV and/or NASH, and determine the utility of combining these markerswith THI for prediction of significant and advanced fibrosis. The studyrevealed that APRI index, modified APRI index and α 2 macroglobulinare the most significant and reliable non invasive factors in predictingHCV and/or NASH related hepatic fibrosis compared to liver biopsybeing the gold standard for diagnosis of fibrosis. They show the bestsensitivity, specificity, P.P.V. and N.P.V. other than haptoglobin andapolipoprotein A1. Visibility with harmonic imaging was better than thatwith conventional ultrasonography, this was most apparent if the BMI ofthe patient increased because of reduction in the deleterious effects of thebody wall.