Patients with chronic renal failure (CRF), including those under-going regular hemodialysis (HD), have an exceptionally high incidence of cardiovascular disease owing to accelerated atherosclerosis, related in part to abnormal lipid metabolism.Despite current availability of numerous new lipid-lowering agents, there is still uncertainty regarding their safety, particularly in those requiring combination drug therapies.On the other hand, as oxidative stress is (OS) present in patients on long-term HD, and the deleterious effect of hyperlipopoteinemia is accelerated by lipid oxidation, antioxidant vitamins might represent a useful tool in the therapeutic arsenal.In addition, there is ample clinical, experimental and epidemiological evidence to suggest that antioxidant vitamins may be an effective and safe alternative therapy for the prevention of atherosclerosis.However, the effects of such supplementation have not been adequately studied on the lipid profile of HD patients, except for supplementary vitamin D, which has been the subject of only a few reports, but with conflicting results.Thus, this comparative study is planned to investigate the tolerability and safety as well as the effect of short-term supplementary vitamin C alone and compare it with statins alone and in combination with statins on the lipid profile of CRF patients on regular HD.