Background and Objectives: The glutaraldehyde-treated autologous pericardium has been proposed as an additional option for the annuloplasty procedure. We hypothesized that, use of such a biological tissue for annular remodeling, have shown excellent results in terms of the short-term efficacy of Mitral valve repair. Methodology: Forty patients with isolated mitral valve disease will be randomized into two groups, group (A): Underwent mitral valve repair using pretreated autologous pericardium for mitral annuloplasty. Group (B): Underwent mitral valve repair using rigid open (Carpetier-Edwards) rings for mitral valve annuloplasty. In group (A), age ranged from 13-63 years with mean of 31.75±17, while in group (B) age ranged from 15-68 years with mean of 32.3±17.7.Additional procedures as, commissurotomy, slidingplasty and chordal shortening have been done, in addition to mitral annuloplasty. Results: There was no statistical significant difference as regards the age, sex, NYHA classification, cardiac rhythm preoperative echocardiographic findings as LVED, PAP, LA dimension, EF and mitral valve pathology. Regarding Intraoperative comparison, there was no statistical significant difference in cross-clamp time, total bypass time, need of inotropic support and LA pressure after coming off bypass. Regarding postoperative comparison (immediately before discharge and 6 months after discharge), there was no statistical significant difference in NYHA classification, postoperative echocardiographic findings as LVED, PAP, EF and degree of mitral regurge. Conclusion: There is no significant difference between both types of rings (pretreated autologous pericardium and rigid Carpentier-Edwards rings) regarding the postoperative haemodynamics and echocardiographic data as PAP, EF and degree of mitral regurge. We support the use of autologous pericardium, as its short-term durability, low thrombogenicity, easy availability and easy handling, offer several advantages.